A bioquímica e professora dos cursos de Fisioterapia e Odontologia da Faculdade Avantis, Darlene Aparecida Pena, desenvolveu um anticorpo que poderá auxiliar no tratamento do câncer de mama. O trabalho, intitulado em tradução livre de “Desenvolvimento e validação racional de um anticorpo contra formas ativas das proteínas quinases C” faz parte da tese de doutorado da docente e foi publicado no periódico Scientific Reports, uma das revistas do Grupo Nature, que está entre as publicações científicas mais importantes do mundo.
Darlene desenvolveu o estudo através do Departamento de Química da Universidade de São Paulo (USP). “A célula possui uma proteína chamada proteína quinase C, que está envolvida em vários processos fundamentais para o nosso corpo. Quando essa proteína está inativa, ela tem uma forma mais fechada. Já quando ela está ativada para exercer suas funções, assume uma forma mais aberta. Sabíamos que em tumores mais agressivos de câncer de mama, essas proteínas estão mais ativadas. Desenvolvemos um anticorpo que reconhece apenas a forma ativa, que está mais aberta”, explica Darlene.
O experimento contou com a colaboração do Hospital A. C Camargo, em São Paulo, onde foram coletadas 134 amostras de tumores provenientes de pacientes com câncer de mama. “Haviam dois grupos de tumores, sendo um deles mais agressivo e outro menos agressivo. Nos casos de câncer mais agressivos, os indivíduos tinham mais metástases e maior reincidência da doença”, relata a professora. “Nós aplicamos esse anticorpo pra desenvolver um novo método pra determinar a agressividade do câncer de mama. O grupo que apresentava um grau de agressividade maior, mostrou um resultado positivo nesse exame. No futuro, este estudo poderá ajudar a determinar o grau de agressividade do câncer e a definir a melhor estratégia de tratamento”, pontua a especialista.
Parte dessa pesquisa também foi realizada no Hospital Mount Sinai, de Nova York, nos Estados Unidos. Por enquanto, a técnica ainda está numa etapa pré-clínica e não pode ser comercializada, mas a intenção é disponibilizar o exame futuramente.
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The aim of COX-2 inhibitors is to reduce ache and inflammation without losing the safety of COX-1 in the gastrointestinal tract.
NSAIDs block an enzyme known as cyclooxygenase (or
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Used by diabetics however co-opted by bodybuilders to realize bulk and enhance stamina, sometimes as part of a “kitchen sink” stack of steroids,
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Uncommon however critical injuries have occurred with non-benzodiazepine sleep drugs including sleepwalking, sleep driving, and doing other actions whereas not totally awake.
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to develop a phencyclidine use dysfunction. Oxycodone is
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There could additionally be a rise in blood pressure,
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Call your physician for directions should you miss
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While extremely effective, they are sometimes used for a brief
time frame to avoid probably serious side effects.
Sleep medicines are misused when they are taken in a way or dose that’s completely different than prescribed, taken without a prescription, or
taken with different medicine to spice up intoxicating results.
The immune system is the body’s natural defence
towards sickness and an infection.
A specialist could present a one-time shot or one shot
per week for as much as 3 weeks. A medical professional draws the blood, and then a lab uses a centrifuge to separate the parts.
A medical skilled then injects the serum immediately into the affected joint.
In most cases, an individual will need weekly injections for 3–5 weeks.
Biologics can successfully deal with arthritis in some people however
not others.
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References:
How To Make Anabolic Steroids At Home (Brewwiki.Win)